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A Novel Technology for Genome-Editing a Broad Range of Mutations in Live Organisms

In the article entitled “A Novel Technology for Genome-Editing a Broad Range of Mutations in Live Organisms: Scientists Develop a New Gene-Editing Tool That Could Help Treat Many Disorders Caused by Gene Mutations”, the researchers have established a novel tool known as SATI for editing the mouse genome, thereby enabling this team of researchers to target a wide range of cell types and mutations. According to Salk Institute (2019), SATI, which represents short for intercellular linearized Single homology Arm donor mediated intron-Targeting Integration, serves as an advancement or improvement of the former HITI technique to enable this tool to target extra genome areas.

The researchers manage to draw a link between normal DNA repair and genome-editing by employing techniques that modify DNA, particularly the CRISPR-Cas9 system in dividing cells in the gut and skin, using the normal repair mechanisms of such cells (Salk Institute, 2019). This development could be employed or applied in a range of gene mutation conditions like progeria or the rare premature syndrome of aging and Huntington’s disease (Salk Institute, 2019). In my view, another issue addressed in the article that should receive extra consideration is how the details associated with the cellular systems that take part in repairing DNA can be employed in refining novel genome editing technologies such as SATI for better correction of DNA.