Agonist-to-antagonist spectrum of action of psychopharmacologic agents,
Post a response to each of the following:
Explain the agonist-to-antagonist spectrum of action of psychopharmacologic agents, including how partial and inverse agonist functionality may impact the efficacy of psychopharmacologic treatments.
Compare and contrast the actions of g couple proteins and ion gated channels.
Explain how the role of epigenetics may contribute to pharmacologic action.
Explain how this information may impact the way you prescribe medications to patients. Include a specific example of a situation or case with a patient in which the psychiatric mental health nurse practitioner must be aware of the medication’s action.
Sample Solution
The agonist-to-antagonist spectrum of action of psychopharmacologic agents involves substances that interact with neurotransmitters to produce either a stimulatory (agonists) or inhibitory (antagonists) effect on neurons. Agonists activate receptors and generate neuronal depolarization, while antagonists prevent receptor activation and reduce neuronal depolarization. Partial agonists bind to the same receptors as agonists but have a lower efficacy, while inverse agonists bind to the same receptors as antagonists and reduce the activity below baseline levels, thus increasing neuronal inhibition. This can impact the efficacy of psychopharmacological treatments by altering how effectively a given substance interacts with its target receptor in order to achieve desired therapeutic effects.
Oviposition, or the laying of eggs, is broken down into pre-oviposition and post-oviposition. In this experiment we observed pre-oviposition factors using the model species Callosobrachus maculatus, commonly known as the bean beetle. Small and large lima beans were used to test whether or not bean beetles had a preferred site size for oviposition. We hypothesized that if a preference was shown, the majority of eggs will be oviposited on the larger lima beans when compared to small lima beans. To do this we placed 15 small and 15 large lima beans in 3 petri dishes, then added 3 female and 2 male bean beetles in each and waited 2 weeks to allow fertilization and oviposition. Because our subject was exposed to both sizes of beans throughout the experiment, we interpreted our results by observing the number of eggs laid on each individual bean. From our observations we calculated the mean, standard deviation, standard error of mean, and for statistical purposes, ran a t-test. We found our results to be statistically significant, therefore we rejected the null hypothesis. From this we can concur that C. maculatus prefers smaller sized beans for oviposition.