Are doctors making mere mistakes or are they negligent or acting in a reckless manner resulting in criminal liability

Are doctors making mere mistakes or are they negligent or acting in a reckless manner resulting in criminal liability?
Should criminal charges be brought without willful misconduct? Should a doctor lose their license? Are there healthcare and/or business reasons that affect such decisions (whether positively or negatively)?
Should homicide charges be brought against a doctor for the misdiagnosis of a patient?
Is there a difference between being overworked and lack of attention (negligence)?
What do you think?