Question
There are various types of anemic conditions, but the overall definition of anemia is that it is a condition in which the blood lacks enough healthy red blood cells in order to meet the body’s physiological requirements (Kishore et al., 2020). Hemolytic anemia is a disorder in which RBCs are destroyed by a specific type of antibodies, which can lead to the development of anemia. This type of anemia can be caused by inheriting the disorder, primary, which is due to idiopathic cause or secondary, which is due to and the underlying cause. A condition that is considered idiopathic when the cause is unknown and underlying causes could be connective tissue disorders, renal failure, hematological disorders, hematological malignancies in tuberculosis, HIV infection, and miscellaneous causes (Habiba, Ilyas, Sijjeel, Tabassum, & Fatima, 2020). According to Schuurman et al. (2015), sickle cell anemia is an inherited autosomal recessive disorder characterized by the production of abnormal hemoglobin S (HbS) within the erythrocytes. HbS is formed by a genetic mutation in which the amino acid valine replaces glutamic acid. This type of disorder is caused by a mutation in the gene, which is inherited by at least one of the parents. The pathophysiological mechanism shared by hemolytic and sickle cell anemia is that they could both be inherited and both destruct/break down red blood cells, hemolysis, which can lead to severe pain.
2.Hemolytic Anemia is a disorder where the red blood cells are destroyed at a faster rate than they are made(Huether & Mccance, 2017). Acquired Hemolytic Anemia is a condition you are not born with but develop later. With this type, you can create normal Red Blood Cells, but they are later destroyed. Etiologies may happen because of viral or bacterial infection, autoimmune disorders, blood cancers, and a severe reaction from a blood transfusion. Whereas, hereditary hemolytic anemia is passed down from the parent's genes to their children((Huether & Mccance, 2017). This condition can produce RBC however they do not live as long as normal blood cells. Both Acquired and Inherited Hemolytic Anemia have two mechanisms 1) Intravascular hemolysis the destruction of RBC where the contents of the cell are released in the plasma. 2) Extravascular hemolysis is the removal of red blood cells with changes to the membrane of the spleen and liver (Guolla & Chan, 2018).
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| Subject | Nursing | Pages | 2 | Style | APA |
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Answer
Pathophysiology of Anemia
- First Post
I agree with the concise manner in which the post defines anemia as a condition that is caused by a lack of red blood cells or dysfunctional red blood cells in the body. It accurately provides the two types of anemia – hemolytic anemia and sickle cell anemia. Additionally, it correctly classifies the hemolytic anemia based on the causes. However, I find the definition of hemolytic anemia in the post to be somehow inaccurate hence since it specific to the cause of anemia to antibody. Consequently, hemolytic anemia is a type of anemic condition that is caused by a low number of red blood cells as a result of excess hemolysis (National Heart, Lung, and Blood Institute, 2020). Hemolysis is the process by which the body destroys old and faulty red blood cells in the spleen. Therefore, it is not caused by the destruction of red blood cells by a specific antibody.
- Second Post
I agree entirely with a post on its precise in the definition of hemolytic anemia condition as a disorder that results due to a faster rate of cell destruction by the body. Additionally, I find it accurate to classify hemolytic anemia as acquired hemolytic anemia, developed from etiologies like infections by pathogens like viruses and bacteria, and other diseases such as blood cancer hereditary hemolytic anemia – which is genetically congenital from parents to offspring. Moreover, I agree with how the post articulated the two mechanisms of hemolytic anemia as intravascular and extravascular hemolysis. Therefore, I am absolutely in agreement accurate and concise definition of the hemolytic anemia, classification, and mechanisms of hemolytic anemia.
References
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National Heart, Lung, and Blood Institute. (2020). Hemolytic Anemia (NHLBI). Nhlbi.nih.gov. Retrieved 17 June 2020, from https://www.nhlbi.nih.gov/health-topics/hemolytic-anemia#:~:text=Conditions%20that%20may%20lead%20to,transfusions%20may%20cause%20hemolytic%20anemia.
Appendix
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